The A342 Andover Road is currently closed between the bottom of Nursteed Road and Planks at Lydeway.
Drivers are being urged to seek an alternative routes while Wiltshire Police deal with the RTC.
The incident is very close to the railway line and the road will remain closed for several more hours- the force has confirmed.
A spokesperson for Wiltshire Police said: 'If you cannot access from the A342, you can take the A360 to West Lavington and turn left at Dauntsey's and approach that way.'
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