Mark Bridger has been charged with the abduction and murder of missing mid Wales schoolgirl April Jones.
Dyfed-Powys Police said the 46-year-old former lifeguard was also charged with perverting the course of justice.
April, five, was snatched from the Bryn-y-Gog estate in Machynlleth on Monday evening.
Iwan Jenkins, the district crown prosecutor from the Crown Prosecution Service (CPS) in Wales, said: "I now have to advise that, having carried out a detailed review of the evidence gathered so far by Dyfed-Powys Police, my conclusion is that there is sufficient evidence to charge Mark Bridger with the murder of April Jones, and that it is in the public interest to do so.
"I have also concluded that there is sufficient evidence to charge the defendant with attempting to pervert the course of justice and child abduction."
He said he will appear before Aberystwyth Magistrates' Court on Monday morning.
Chief Constable Jackie Roberts said in a press conference in Aberystwyth the investigation was "one of the most complex and fast moving inquiries in the history of our force".
She said: "Now that Mark Bridger has been charged with this horrific crime it is time to let the judicial process take its course and time to let the family come to terms with what has happened over the last week.
"In the meantime our efforts to find April will be as meticulous as they have been from the outset of this inquiry until we have exhausted all available options."
Police said the hunt for missing April was continuing after searchers were stood down on Friday night due to atrocious weather.